Dcc regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

Laura Morcom, Ilan Gobius, Ashley P.L. Marsh, Rodrigo Suárez, Jonathan W.C. Lim, Caitlin Bridges, Yunan Ye, Laura R. Fenlon, Yvrick Zagar, Amelia M. Douglass, Amber Lee S. Donahoo, Thomas Fothergill, Samreen Shaikh, Peter Kozulin, Timothy J. Edwards, Helen M. Cooper, I. R.C. Consortium, Elliott H. Sherr, Alain Chédotal, Richard J. LeventerPaul J. Lockhart, Linda J. Richards

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in Dcc and Ntn1 knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with DCC mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it.

Original languageEnglish
Article numbere61769
JournaleLife
Volume10
DOIs
StatePublished - Apr 2021

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