DAP12 regulates the osteoclast cytoskeleton

Wei Zou; Steven L. Teitelbaum

doi:10.1007/978-1-4614-5366-6_13

DAP12 regulates the osteoclast cytoskeleton

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The primary ITAM-containing signaling adapters, in osteoclast lineage cells, are DAP12 and the FcεRIγ chain (FcRγ). Each associates with specific immunoreceptors. DAP12 associates with the receptors TREM2 and SIRPβ1 [1], while FcRγ recognizes OSCAR [2, 3]. Both molecules also contain an ITAM motif, within their cytoplasmic domains, whose phosphorylated tyrosines provide a high-affinity binding site for Syk family kinases.

Original language	English
Title of host publication	Osteoimmunology
Subtitle of host publication	Interactions of the immune and skeletal systems
Publisher	Springer New York
Pages	115-120
Number of pages	6
ISBN (Electronic)	9781461453666
ISBN (Print)	1461453658, 9781461453659
DOIs	https://doi.org/10.1007/978-1-4614-5366-6_13
State	Published - Oct 1 2013

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AB - The primary ITAM-containing signaling adapters, in osteoclast lineage cells, are DAP12 and the FcεRIγ chain (FcRγ). Each associates with specific immunoreceptors. DAP12 associates with the receptors TREM2 and SIRPβ1 [1], while FcRγ recognizes OSCAR [2, 3]. Both molecules also contain an ITAM motif, within their cytoplasmic domains, whose phosphorylated tyrosines provide a high-affinity binding site for Syk family kinases.

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DAP12 regulates the osteoclast cytoskeleton

Abstract

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