The primary ITAM-containing signaling adapters, in osteoclast lineage cells, are DAP12 and the FcεRIγ chain (FcRγ). Each associates with specific immunoreceptors. DAP12 associates with the receptors TREM2 and SIRPβ1 [1], while FcRγ recognizes OSCAR [2, 3]. Both molecules also contain an ITAM motif, within their cytoplasmic domains, whose phosphorylated tyrosines provide a high-affinity binding site for Syk family kinases.

Original languageEnglish
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the immune and skeletal systems
PublisherSpringer New York
Number of pages6
ISBN (Electronic)9781461453666
ISBN (Print)1461453658, 9781461453659
StatePublished - Oct 1 2013


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