Dancing partners at the synapse: Auxiliary subunits that shape kainate receptor function

Bryan A. Copits, Geoffrey T. Swanson

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations

Abstract

Kainate receptors are a family of ionotropic glutamate receptors whose physiological roles differ from those of other subtypes of glutamate receptors in that they predominantly serve as modulators, rather than mediators, of synaptic transmission. Neuronal kainate receptors exhibit unusually slow kinetic properties that have been difficult to reconcile with the behaviour of recombinant kainate receptors. Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.

Original languageEnglish
Pages (from-to)675-686
Number of pages12
JournalNature Reviews Neuroscience
Volume13
Issue number10
DOIs
StatePublished - Oct 2012

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