D-serine, a new modulator of NMDA receptor

Fu jun Chen; De fu He; Shao ci Zhou

D-serine, a new modulator of NMDA receptor

Fu jun Chen
, De fu He
, Shao ci Zhou

Department of Neuroscience

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The viewpoint that there is no endogenous D-serine in mammalian nervous system has changed based on recent published reports. The studies indicated that the distribution of this kind of endogenous D-serine parallels with that of NMDA receptor in nervous system. Further study suggested that the D-serine produced in astrocytes regulates the function of NMDA receptor through the glycine-binding site of the receptor. This paper reviews the distribution, synthesis and physiological function of D-serine in nervous system.

Original language	English
Pages (from-to)	127-129
Number of pages	3
Journal	Chinese Journal of Neuroscience
Volume	19
Issue number	2
State	Published - 2003

Keywords

D-Ser
Modulator
NMDA receptor

Cite this

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title = "D-serine, a new modulator of NMDA receptor",

abstract = "The viewpoint that there is no endogenous D-serine in mammalian nervous system has changed based on recent published reports. The studies indicated that the distribution of this kind of endogenous D-serine parallels with that of NMDA receptor in nervous system. Further study suggested that the D-serine produced in astrocytes regulates the function of NMDA receptor through the glycine-binding site of the receptor. This paper reviews the distribution, synthesis and physiological function of D-serine in nervous system.",

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TY - JOUR

T1 - D-serine, a new modulator of NMDA receptor

AU - Chen, Fu jun

AU - He, De fu

AU - Zhou, Shao ci

PY - 2003

Y1 - 2003

N2 - The viewpoint that there is no endogenous D-serine in mammalian nervous system has changed based on recent published reports. The studies indicated that the distribution of this kind of endogenous D-serine parallels with that of NMDA receptor in nervous system. Further study suggested that the D-serine produced in astrocytes regulates the function of NMDA receptor through the glycine-binding site of the receptor. This paper reviews the distribution, synthesis and physiological function of D-serine in nervous system.

AB - The viewpoint that there is no endogenous D-serine in mammalian nervous system has changed based on recent published reports. The studies indicated that the distribution of this kind of endogenous D-serine parallels with that of NMDA receptor in nervous system. Further study suggested that the D-serine produced in astrocytes regulates the function of NMDA receptor through the glycine-binding site of the receptor. This paper reviews the distribution, synthesis and physiological function of D-serine in nervous system.

KW - D-Ser

KW - Modulator

KW - NMDA receptor

UR - https://www.scopus.com/pages/publications/0037246054

M3 - Review article

AN - SCOPUS:0037246054

SN - 1008-0872

VL - 19

SP - 127

EP - 129

JO - Chinese Journal of Neuroscience

JF - Chinese Journal of Neuroscience

IS - 2

ER -

D-serine, a new modulator of NMDA receptor

Abstract

Keywords

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