Zytotoxische T-Lymphozyten und die Erkennung von Tumorantigenen - Ein Weg zur 'Tumorschutzimpfung?

Translated title of the contribution: Cytotoxic T-lymphocytes and the recognition of tumor antigens. An approach to anti-tumor vaccines?

M. Peiper, Simon Goedegebuure, Timothy Eberlein, C. Zornig

Research output: Contribution to journalReview article

Abstract

In spite of modifications of the intra- and postoperative therapeutic strategy as well as new adjuvant protocols, most malignant diseases have a poor prognosis. This demonstrates the need for new approaches in tumor therapy. One alternative is adoptive immunotherapy (AIT). AIT is based on the observation that cytotoxic T-lymphocytes (CTL) may be generated with the ability to lyse autologous tumor cells in vitro and in vivo. Aim of current research activities is to determine specific tumorantigens and the clinical applicability of cell-mediated immunotherapy. The immunobiology of the cell-mediated immune response to cancer with focus on major-histocompatibility complex class I and CD8 + T cells is reviewed. Recent advances in the identification of tumor-associated and tumor-specific antigens were summarized. Previously performed clinical studies were reviewed. We examined the implications that the discovery of theses antigens might have on the development of new anticancer vaccines.

Translated title of the contributionCytotoxic T-lymphocytes and the recognition of tumor antigens. An approach to anti-tumor vaccines?
Original languageGerman
Pages (from-to)141-148
Number of pages8
JournalZentralblatt fur Chirurgie
Volume122
Issue number3
StatePublished - May 24 1997

Keywords

  • CD8 lymphocytes
  • adoptive immunotherapy
  • solid tumors
  • tumor antigens
  • tumor-associated antigens

Fingerprint Dive into the research topics of 'Cytotoxic T-lymphocytes and the recognition of tumor antigens. An approach to anti-tumor vaccines?'. Together they form a unique fingerprint.

  • Cite this