Keyphrases
Endoplasmic Reticulum Stress (ER stress)
100%
Cholesterol
100%
Cancer Cell Death
100%
Sigma-2 Ligand
100%
Cytotoxicity
40%
Cholesterol Homeostasis
20%
Free Cholesterol
20%
Simvastatin
20%
ER Stress Response
20%
RNA Sequencing (RNA-seq)
10%
Mouse Model
10%
Tumor Cells
10%
Cell Death
10%
Niemann-Pick C1-like 1 (NPC1L1)
10%
Quantitative PCR
10%
Low-density Lipoprotein Receptor
10%
High Affinity
10%
Cargo
10%
Cancer Cell Lines
10%
Treatment Outcome
10%
Binding Affinity
10%
Delivery Vehicle
10%
Cancer Therapeutics
10%
Pro-survival
10%
Survival Factor
10%
Sigma-2 Receptor
10%
Ligand-mediated
10%
Imaging Probe
10%
Adaptive Response
10%
Lipid Analysis
10%
Cellular Models
10%
Intracellular Cholesterol Transport
10%
Gene Cluster
10%
Stress Markers
10%
Cholesterol Accumulation
10%
Cholesterol Ester
10%
Stress Inducers
10%
Cytotoxic Drugs
10%
Cytotoxicity Profile
10%
Synergistic Treatment
10%
Downstream Process
10%
Tumor Eradication
10%
Drug Conjugates
10%
Erastin
10%
Cytotoxic Profile
10%
Confocal Microscopy Analysis
10%
Enhanced Cytotoxicity
10%
Sterol Regulatory Element Binding Protein 2
10%
Targeted Modulation
10%
Ligand-drug Conjugate
10%
Biochemistry, Genetics and Molecular Biology
Cancer Cell
100%
Endoplasmic Reticulum Stress
100%
Cell Death
100%
Cytotoxicity
85%
Homeostasis
28%
Simvastatin
28%
Real-Time Polymerase Chain Reaction
14%
RNA Sequence
14%
Mouse Model
14%
Binding Affinity
14%
Gene Cluster
14%
Confocal Microscopy
14%
Conjugate
14%
Lipidomics
14%
NPC1
14%
Survival Factor
14%
LDL Receptor
14%
Adaptive Response
14%
Sterol Regulatory Element Binding Protein 2
14%
Immunology and Microbiology
Endoplasmic Reticulum Stress
100%
Cell Death
100%
Cancer Cell
100%
Cytotoxicity
85%
Homeostasis
28%
Mouse Model
14%
Tumor Cell
14%
Real-Time Polymerase Chain Reaction
14%
Gene Cluster
14%
RNA Sequence
14%
Conjugate
14%
Binding Affinity
14%
Survival Factor
14%
Cancer Cell Line
14%
Sterol Regulatory Element Binding Protein 2
14%
Confocal Microscopy
14%
Low-Density Lipoprotein
14%
Pharmacology, Toxicology and Pharmaceutical Science
Malignant Neoplasm
100%
Cytotoxicity
100%
Neoplasm
33%
Simvastatin
33%
Drug Conjugate
33%
Mouse Model
16%
Confocal Microscopy
16%
Low Density Lipoprotein Receptor
16%
Survival Factor
16%
Sigma 2 Opiate Receptor
16%
RNA-Sequencing
16%
Cholesterol Ester
16%
Sterol Regulatory Element Binding Protein 2
16%
Cytotoxic Agent
16%