Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase

Christopher L. Holley; Melissa W. Li; Benjamin S. Scruggs; Scot J. Matkovich; Daniel S. Ory; Jean E. Schaffer

doi:10.1074/jbc.M115.637413

Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase

Christopher L. Holley, Melissa W. Li, Benjamin S. Scruggs, Scot J. Matkovich, Daniel S. Ory, Jean E. Schaffer

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Background: Small nucleolar RNAs (snoRNAs) are thought to be exclusively nuclear. Results: Doxorubicin stress results in significant accumulation of cytosolic snoRNAs via a pathway involving Nox4D and superoxide. Conclusion: snoRNAs are present in the cytoplasm and their cytosolic abundance is dynamically regulated. Significance: Previously unexplained snoRNA biology may be the result of snoRNA interactions with cytoplasmic targets.

Original language	English
Pages (from-to)	11741-11748
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M115.637413
State	Published - May 1 2015

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title = "Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase",

abstract = "Background: Small nucleolar RNAs (snoRNAs) are thought to be exclusively nuclear. Results: Doxorubicin stress results in significant accumulation of cytosolic snoRNAs via a pathway involving Nox4D and superoxide. Conclusion: snoRNAs are present in the cytoplasm and their cytosolic abundance is dynamically regulated. Significance: Previously unexplained snoRNA biology may be the result of snoRNA interactions with cytoplasmic targets.",

author = "Holley, {Christopher L.} and Li, {Melissa W.} and Scruggs, {Benjamin S.} and Matkovich, {Scot J.} and Ory, {Daniel S.} and Schaffer, {Jean E.}",

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AU - Holley, Christopher L.

AU - Li, Melissa W.

AU - Scruggs, Benjamin S.

AU - Matkovich, Scot J.

AU - Ory, Daniel S.

AU - Schaffer, Jean E.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: Small nucleolar RNAs (snoRNAs) are thought to be exclusively nuclear. Results: Doxorubicin stress results in significant accumulation of cytosolic snoRNAs via a pathway involving Nox4D and superoxide. Conclusion: snoRNAs are present in the cytoplasm and their cytosolic abundance is dynamically regulated. Significance: Previously unexplained snoRNA biology may be the result of snoRNA interactions with cytoplasmic targets.

AB - Background: Small nucleolar RNAs (snoRNAs) are thought to be exclusively nuclear. Results: Doxorubicin stress results in significant accumulation of cytosolic snoRNAs via a pathway involving Nox4D and superoxide. Conclusion: snoRNAs are present in the cytoplasm and their cytosolic abundance is dynamically regulated. Significance: Previously unexplained snoRNA biology may be the result of snoRNA interactions with cytoplasmic targets.

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DO - 10.1074/jbc.M115.637413

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JF - Journal of Biological Chemistry

IS - 18

ER -

Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase

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