Cytoskeletal remodeling in lymphocyte activation

Ana V. Miletic, Maciej Swat, Keiko Fujikawa, Wojciech Swat

Research output: Contribution to journalReview article

62 Scopus citations

Abstract

The formerly distinct fields of lymphocyte signal transduction and cytoskeletal remodeling have recently become linked, as proteins involved in transducing signals downstream of lymphocyte antigen receptors have also been implicated in actin cytoskeleton remodeling, microtubule dynamics and regulation of cell polarity. These discoveries have fuelled interest in understanding both the role of the actin cytoskeleton as an integral component of lymphocyte activation and the interplay between lymphoid cell-cell contact sites (immunological synapse), retractile pole structures (uropod, distal pole complex), and Rho-family GTPases (Rac, Rho, Cdc42), their upstream activators (Dbl-family guanine nucleotide exchange factors) and their downstream effectors (WASp, Arp2/3, ADAP). To understand how these complex regulatory networks are wired, a new breed of computational biologists uses mathematical language to reproduce and simulate signaling circuits 'in silico'.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalCurrent Opinion in Immunology
Volume15
Issue number3
DOIs
StatePublished - Jun 2003

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