TY - JOUR
T1 - Cytomegalovirus and HLA-A, B, and DR locus interactions
T2 - Impact on renal transplant graft survival
AU - Schnitzler, Mark A.
AU - Woodward, Robert S.
AU - Brennan, Daniel C.
AU - Phelan, Donna L.
AU - Spitznagel, Edward L.
AU - Boxerman, Stuart B.
AU - Dunagan, William C.
AU - Bailey, Thomas C.
N1 - Funding Information:
From The Health Administration Program and the Department of Internal Medicine, School of Medicine, and the Department of Mathematics, Washington University, St Louis, MO; and Barnes-Jewish Hospital, St Louis, MO. Received January 23, 1997; accepted in revisedform 20, 1997. Supported in part by Grant No. ROI -DK-47801-OIAI from the National Institute of Diabetes and Digestive and Kidney Diseases. The data reported here have been supplied by the US Renal Data System (USRDS). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the US government. Address reprint requests to Mark A. Schnitzler, PhD, The Health Administration Program, Washington University School of Medicine, 4547 Clayton Ave, St Louis, MO 63110. E-mail: [email protected] 0 1997 by the National Kidney Foundation, 0272.6386/97/3006-0006$3.00/O
PY - 1997/12
Y1 - 1997/12
N2 - Graft failure rates for renal transplantations performed between 1989 and 1994 and recorded in the US Renal Data System database were retrospectively evaluated for interactions between cytomegalovirus and HLA- A, B, and DR loci. Twelve significant interactions were observed. There were significantly greater risks of graft failure for the total effect of cytomegalovirus and donor or matched HLA-DR9, recipient or matched HLA-B-51, and matched HLA-B13. We conclude that further study of renal transplants with these combinations of cytomegalovirus and HLA loci is needed to determine whether the observed interactions should be taken into consideration when matching donors with recipients.
AB - Graft failure rates for renal transplantations performed between 1989 and 1994 and recorded in the US Renal Data System database were retrospectively evaluated for interactions between cytomegalovirus and HLA- A, B, and DR loci. Twelve significant interactions were observed. There were significantly greater risks of graft failure for the total effect of cytomegalovirus and donor or matched HLA-DR9, recipient or matched HLA-B-51, and matched HLA-B13. We conclude that further study of renal transplants with these combinations of cytomegalovirus and HLA loci is needed to determine whether the observed interactions should be taken into consideration when matching donors with recipients.
KW - Cytomegalovirus
KW - HLA typing
KW - Kidney
KW - Proportional hazards models
UR - http://www.scopus.com/inward/record.url?scp=0030732498&partnerID=8YFLogxK
U2 - 10.1016/S0272-6386(97)90080-9
DO - 10.1016/S0272-6386(97)90080-9
M3 - Article
C2 - 9398119
AN - SCOPUS:0030732498
SN - 0272-6386
VL - 30
SP - 766
EP - 771
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 6
ER -