Cytokines in heart failure: Pathogenetic mechanisms and potential treatment

Z. Dibbs, K. Kurrelmeyer, D. Kalra, Y. Seta, F. Wang, B. Bozkurt, G. Baumgarten, N. Sivasubramanian, D. L. Mann

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Recent studies have shown that patients with heart failure overexpress a class of biologically active molecules, generically referred to as pro- inflammatory cytokines. This article will review recent clinical and experimental material that suggests that pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) may play a role in the pathogenesis of congestive heart failure. In addition, we will review recent studies that suggest that antagonizing cytokines may represent a novel target for heart failure therapy.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalProceedings of the Association of American Physicians
Issue number5
StatePublished - 1999


  • Cardiomyopathy
  • Interleukin-1
  • Interleukin-6
  • Left ventricular remodeling
  • Tumor necrosis factor-α


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