Cytokines as emerging targets in the treatment of heart failure

Georg Baumgarten, Pascal Knuefermann, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations


Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones another portfolio of biologically active molecules termed cytokines are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material which suggest that the cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) may represent another class of biologically active molecules that are responsible for the development and progression of heart failure. In addition, we also review the early results from clinical trials that have utilized various targeted anti-cytokine strategies in patients with heart failure.

Original languageEnglish
Pages (from-to)216-223
Number of pages8
JournalTrends in Cardiovascular Medicine
Issue number5
StatePublished - 2000


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