TY - JOUR
T1 - Cytokines and chemokines in Mycobacterium tuberculosis infection
AU - Domingo-Gonzalez, Racquel
AU - Prince, Oliver
AU - Cooper, Andrea
AU - Khader, Shabaana A.
N1 - Publisher Copyright:
© 2016 American Society for Microbiology. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the "goldilocks" (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.
AB - Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected lungs. Correct mononuclear cellular recruitment and localization are essential to ensure control of bacterial growth without the development of diffuse and damaging granulocytic inflammation. An important block to our understanding of TB pathogenesis lies in dissecting the critical aspects of the cytokine/chemokine interplay in light of the conditional role these molecules play throughout infection and disease development. Much of the data highlighted in this review appears at first glance to be contradictory, but it is the balance between the cytokines and chemokines that is critical, and the "goldilocks" (not too much and not too little) phenomenon is paramount in any discussion of the role of these molecules in TB. Determination of how the key chemokines/cytokines and their receptors are balanced and how the loss of that balance can promote disease is vital to understanding TB pathogenesis and to identifying novel therapies for effective eradication of this disease.
UR - http://www.scopus.com/inward/record.url?scp=85011688951&partnerID=8YFLogxK
U2 - 10.1128/microbiolspec.TBTB2-0018-2016
DO - 10.1128/microbiolspec.TBTB2-0018-2016
M3 - Article
C2 - 27763255
AN - SCOPUS:85011688951
SN - 2165-0497
VL - 4
JO - Microbiology spectrum
JF - Microbiology spectrum
IS - 5
M1 - TBTB2-0018-2016
ER -