Cytokine-mediated inflammation in acute lung injury

Richard B. Goodman, Jérôme Pugin, Janet S. Lee, Michael A. Matthay

Research output: Contribution to journalReview articlepeer-review

616 Scopus citations


Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill patients. There is considerable experimental and clinical evidence that pro- and anti-inflammatory cytokines play a major role in the pathogenesis of inflammatory-induced lung injury from sepsis, pneumonia, aspiration, and shock. A recent multi-center clinical trial found that a lung-protective ventilatory strategy reduces mortality by 22% in patients with ALI. Interestingly, this protective ventilatory strategy was associated with a marked reduction in the number of neutrophils and the concentration of pro-inflammatory cytokines released into the airspaces of the injured lung. Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALI.

Original languageEnglish
Pages (from-to)523-535
Number of pages13
JournalCytokine and Growth Factor Reviews
Issue number6
StatePublished - Dec 2003


  • Acute respiratory distress syndrome (ARDS)
  • Chemokine
  • Interleukins
  • Pulmonary edema


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