Cytokine-independent upregulation of MDA5 in viral infection

Jacob S. Yount, Thomas M. Moran, Carolina B. López

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


The RNA helicases RIG-I and MDA5 detect virus infection of dendritic cells (DCs) leading to cytokine induction. Maximal sensitivity for virus detection by these helicases is obtained after their upregulation, which is thought to occur primarily through type I interferon (IFN) signaling. Here we demonstrate that in response to paramyxovirus infection, RIG-I upregulation requires type I IFN whereas MDA5 expression is increased by Sendai virus infection independently of signaling mediated by type I IFN, STAT1, tumor necrosis factor alpha, or NF-κB. This MDA5 upregulation is largely lost in IRF3 knockout DCs and is achieved in type I IFN-deficient cells expressing constitutively active IRF3.

Original languageEnglish
Pages (from-to)7316-7319
Number of pages4
JournalJournal of virology
Issue number13
StatePublished - Jul 2007


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