Cystic fibrosis related diabetes: Medical management

Katie Larson Ode, Christine L. Chan, Andrea Granados, Amir Moheet, Antoinette Moran, Amanda L. Brennan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cystic Fibrosis Related Diabetes Mellitus (CFRD) drives excess pulmonary morbidity and mortality in patients with cystic fibrosis (CF). The recommended treatment is insulin therapy. Insulin therapy in CF should be customized to the specific patient. CF patients typically require intensive insulin regimens such as multiple daily injections or insulin pump therapy, but frequently require lower doses than in type 1 diabetes mellitus. Patients with CF may also need insulin to cover intravenous or enteral feedings. Pre-diabetic glycaemic abnormalities are also associated with clinical decline in cystic fibrosis prior to the diagnosis of CFRD, however, whether and how this should be treated is not fully determined. There is also interest, but inadequate data regarding other treatments besides insulin (i.e., oral medications) for treatment of pre-diabetes or CFRD. CFTR potentiator and corrector therapy has yet to demonstrate an effect on the rate of CFRD, but may improve insulin secretion. There is great opportunity for further research to better understand when and how best to treat glycaemic abnormalities in cystic fibrosis.

Original languageEnglish
Pages (from-to)S10-S18
JournalJournal of Cystic Fibrosis
Volume18
DOIs
StatePublished - Oct 2019

Keywords

  • Cystic fibrosis
  • Cystic fibrosis related diabetes mellitus
  • Insulin
  • Insulin pump
  • Oral hypoglycaemic agents
  • Treatment

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    Ode, K. L., Chan, C. L., Granados, A., Moheet, A., Moran, A., & Brennan, A. L. (2019). Cystic fibrosis related diabetes: Medical management. Journal of Cystic Fibrosis, 18, S10-S18. https://doi.org/10.1016/j.jcf.2019.08.003