Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs

P. B. Zanaboni, J. D. Bradley, R. O. Webster, T. E. Dahms

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The effect of three chemically dissimilar cyclooxygenase inhibitors on ethchlorvynol-(ECV) induced acute lung injury was studied in isolated buffer-perfused rat and blood-perfused rabbit lungs. ECV caused the microvascular fluid filtration coefficient (K(f)) to increase by greater than threefold in the rat lungs and twofold in the rabbit lungs. ECV caused increased pulmonary vascular resistance (PVR) and microvascular pressure measured by the double occlusion technique (Pdo) compared with the vehicle control group in the rat experiments. However, ECV had no effect on PVR or Pdo in the rabbit experiments. Pretreatment with the cyclooxygenase inhibitors indomethacin, ibuprofen, and meclofenamate prevented the increase in microvascular permeability in both the rat and rabbit lung preparations. The cyclooxygenase inhibitors also prevented the ECV-induced PVR and Pdo increases in the rat lungs but had no effect on PVR or Pdo in the rabbit lungs. These results indicate that cyclooxygenase products of arachidonate metabolism mediate the ECV-induced K(f) increase in both isolated rat and rabbit lungs.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalJournal of Applied Physiology
Issue number1
StatePublished - 1991


  • ibuprofen
  • indomethacin
  • isolated perfused rabbit lungs
  • isolated perfused rat lungs
  • meclofenamate
  • microvascular fluid filtration coefficient
  • vascular permeability


Dive into the research topics of 'Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs'. Together they form a unique fingerprint.

Cite this