Cyclooxygenase-2 inhibitors: A new class of anti-inflammatory agents that spare the gastrointestinal tract

J. L. Masferrer, P. C. Isakson, K. Seibert

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

NSAIDs are potent anti-inflammatory and analgesic agents. It is now believed that NSAIDs exert their therapeutic activity through the inhibition of COX-2 at the site of inflammation. Unfortunately, these compounds are equally capable of inhibiting constitutively expressed COX-1 in tissues such as the gastrointestinal tract and kidney, which results in serious, mechanism-based toxicities that limit the drug's therapeutic utility. With the identification of COX-2 inhibitors, alternatives to traditional NSAID therapy should be available that will provide clinical usefulness with reduced toxicity.

Original languageEnglish
Pages (from-to)363-372
Number of pages10
JournalGastroenterology Clinics of North America
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1996

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