CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions

Enrique Alvarez, Laura Piccio, Robert J. Mikesell, Eric C. Klawiter, Becky J. Parks, Robert T. Naismith, Anne H. Cross

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.

Original languageEnglish
Pages (from-to)1204-1208
Number of pages5
JournalMultiple Sclerosis Journal
Volume19
Issue number9
DOIs
StatePublished - Aug 2013

Keywords

  • CXCL13
  • Multiple sclerosis
  • biomarker
  • myelin basic protein
  • neurofilament
  • neuroinflammation
  • neuromyelitis optica

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