TY - JOUR
T1 - CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions
AU - Alvarez, Enrique
AU - Piccio, Laura
AU - Mikesell, Robert J.
AU - Klawiter, Eric C.
AU - Parks, Becky J.
AU - Naismith, Robert T.
AU - Cross, Anne H.
PY - 2013/8
Y1 - 2013/8
N2 - CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.
AB - CXCL13, a B-cell chemokine, has been proposed as a biomarker in a variety of conditions, some of which can mimic multiple sclerosis and can have very high levels. In this case-control study, cerebrospinal fluid (CSF) CXCL13 was elevated in multiple sclerosis, neuromyelitis optica and other inflammatory neurological controls compared with noninflammatory controls. Levels did not differentiate disease groups. For all subjects taken together, CSF CXCL13 correlated with CSF WBC, oligoclonal band numbers, CSF protein, EDSS, and neurofilament levels. In subgroup analyses, CSF CXCL13 correlated with CSF WBC in neuromyelitis optica and IgG index in multiple sclerosis. Additionally, serum CXCL13 was elevated in neuromyelitis optica.
KW - CXCL13
KW - Multiple sclerosis
KW - biomarker
KW - myelin basic protein
KW - neurofilament
KW - neuroinflammation
KW - neuromyelitis optica
UR - http://www.scopus.com/inward/record.url?scp=84879881949&partnerID=8YFLogxK
U2 - 10.1177/1352458512473362
DO - 10.1177/1352458512473362
M3 - Article
C2 - 23322500
AN - SCOPUS:84879881949
SN - 1352-4585
VL - 19
SP - 1204
EP - 1208
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 9
ER -