Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus

Brittany N. Teague, Yujun Pan, Philip A. Mudd, Britt Nakken, Qingzhao Zhang, Peter Szodoray, Xana Kim-Howard, Patrick C. Wilson, A. Darise Farris

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

As the immediate precursors to mature follicular B cells in splenic development, immature transitional cells are an essential component for understanding late B cell differentiation. It has been shown that T2 cells can give rise to mature B cells; however, whether T3 B cells represent a normal stage ofB cell development, which has been widely assumed, has not been fully resolved. In this study, we demonstrate both in vitro and in vivo that T3 B cells do not give rise to mature B cells and are instead selected away from the T1→T2→mature B cell developmental pathway and are hyporesponsive to stimulation through the BCR. Significantly reduced numbers of T3 B cells in young lupus-prone mice further suggest that the specificity of this subset holds clues to understanding autoimm unity.

Original languageEnglish
Pages (from-to)7511-7515
Number of pages5
JournalJournal of Immunology
Volume178
Issue number12
DOIs
StatePublished - Jun 15 2007

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