Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses

Daniel Kreisel, Steven B. Richardson, Wenjun Li, Xue Lin, Christopher G. Kornfeld, Seiichiro Sugimoto, Chyi Song Hsieh, Andrew E. Gelman, Alexander S. Krupnick

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The interaction of CD4+ T cells with MHC class II (MHCII)-expressing hematopoietic APCs plays a critical role in both the generation of protective immune responses and maintenance of tolerance in the lung. The functional significance of MHCII expression by nonhematopoietic stromal cells, however, has not been defined in vivo. Using a novel mouse model of orthotopic left lung transplantation, we demonstrate that selective elimination of MHCII expression on nonhematopoietic cells leads to an inflammatory response as a result of reduced peripheral generation of regulatory CD4+ T cells. Absence of MHCII expression on nonhematopoietic cells also inhibits local growth of metastatic pulmonary tumor. These findings indicate that nonhematopoietic cells play a previously unrecognized role in downregulating inflammatory responses in nonlymphoid tissues.

Original languageEnglish
Pages (from-to)3809-3813
Number of pages5
JournalJournal of Immunology
Volume185
Issue number7
DOIs
StatePublished - Oct 1 2010

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