TY - JOUR
T1 - Cutting edge
T2 - Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain
AU - Nakajima, Hideo
AU - Samaridis, Jacqueline
AU - Angman, Lena
AU - Colonna, Marco
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcεRIγ rather than DAP12.
AB - Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcεRIγ rather than DAP12.
UR - http://www.scopus.com/inward/record.url?scp=0032607844&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.162.1.5
DO - 10.4049/jimmunol.162.1.5
M3 - Article
C2 - 9886363
AN - SCOPUS:0032607844
SN - 0022-1767
VL - 162
SP - 5
EP - 8
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -