Cutting edge: Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain

Hideo Nakajima, Jacqueline Samaridis, Lena Angman, Marco Colonna

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcεRIγ rather than DAP12.

Original languageEnglish
Pages (from-to)5-8
Number of pages4
JournalJournal of Immunology
Volume162
Issue number1
StatePublished - Jan 1 1999

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