TY - JOUR
T1 - Cutting edge
T2 - Human CD49e- NK cells are tissue resident in the liver
AU - Aw Yeang, Han Xian
AU - Piersma, Sytse J.
AU - Lin, Yiing
AU - Yang, Liping
AU - Malkova, Olga N.
AU - Miner, Cathrine
AU - Krupnick, Alexander S.
AU - Chapman, William C.
AU - Yokoyama, Wayne M.
N1 - Publisher Copyright:
Copyright © 2017 by The American Association of Immunologists, Inc.
PY - 2017/2/15
Y1 - 2017/2/15
N2 - Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e- NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.
AB - Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e- NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.
UR - http://www.scopus.com/inward/record.url?scp=85014730476&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1601818
DO - 10.4049/jimmunol.1601818
M3 - Article
C2 - 28093522
AN - SCOPUS:85014730476
SN - 0022-1767
VL - 198
SP - 1417
EP - 1422
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -