Cutting edge: Activation of virus-specific CD4 T cells throughout γ-herpesvirus latency

Michael L. Freeman, Claire E. Burkum, Kathleen G. Lanzer, Meghan K. Jensen, Mushtaq Ahmed, Eric J. Yager, Emilio Flanõ, Gary M. Winslow, David L. Woodland, Marcia A. Blackman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


CD4 T cells are essential for immune control of γ-herpesvirus latency. We previously identified a murine MHC class II-restricted epitope in γ-herpesvirus-68 gp150 (gp150 67-83I-A b) that elicits CD4 T cells that are maintained throughout long-term infection. However, it is unknown whether naive cells can be recruited into the antiviral CD4 T cell pool during latency. In this study, we generate a mouse transgenic for a gp150-specific TCR and show epitope-specific activation of transgenic CD4 T cells during acute and latent infections. Furthermore, although only dendritic cells can stimulate virus-specific CD8 T cells during latency, we show that both dendritic cells and B cells stimulate transgenic CD4 T cells. These studies demonstrate that naive CD4 T cells specific for a viral glycoprotein can be stimulated throughout infection, even during quiescent latency, suggesting that CD4 T cell memory is maintained in part by the continual recruitment of naive cells.

Original languageEnglish
Pages (from-to)6180-6184
Number of pages5
JournalJournal of Immunology
Issue number12
StatePublished - Dec 15 2011


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