Cutis laxa: A review

David R. Berk; Danette D. Bentley; Susan J. Bayliss; Anne Lind; Zsolt Urban

doi:10.1016/j.jaad.2011.01.004

Cutis laxa: A review

David R. Berk, Danette D. Bentley, Susan J. Bayliss, Anne Lind, Zsolt Urban

Division of Dermatology

Research output: Contribution to journal › Review article › peer-review

161 Scopus citations

Abstract

Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.

Original language	English
Pages (from-to)	842.e1-842.e17
Journal	Journal of the American Academy of Dermatology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1016/j.jaad.2011.01.004
State	Published - May 2012

Keywords

cutis laxa
elastic tissue
elastin
fibulin-4
fibulin-5
genodermatosis

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10.1016/j.jaad.2011.01.004

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title = "Cutis laxa: A review",

abstract = "Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.",

keywords = "cutis laxa, elastic tissue, elastin, fibulin-4, fibulin-5, genodermatosis",

author = "Berk, {David R.} and Bentley, {Danette D.} and Bayliss, {Susan J.} and Anne Lind and Zsolt Urban",

note = "Funding Information: Funded in part by National Institutes of Health grants HL073703, HL084922, and HL090648 and March of Dimes grant 1-FY09-402 to Dr Urban. ",

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T2 - A review

AU - Berk, David R.

AU - Bentley, Danette D.

AU - Bayliss, Susan J.

AU - Lind, Anne

AU - Urban, Zsolt

N1 - Funding Information: Funded in part by National Institutes of Health grants HL073703, HL084922, and HL090648 and March of Dimes grant 1-FY09-402 to Dr Urban.

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N2 - Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.

AB - Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.

KW - cutis laxa

KW - elastic tissue

KW - elastin

KW - fibulin-4

KW - fibulin-5

KW - genodermatosis

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DO - 10.1016/j.jaad.2011.01.004

M3 - Review article

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AN - SCOPUS:84859808257

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 5

ER -

Cutis laxa: A review

Abstract

Keywords

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