TY - JOUR
T1 - Cutaneous myeloid sarcoma
T2 - Natural history and biology of an uncommon manifestation of acute myeloid leukemia
AU - Hurley, M. Yadira
AU - Ghahramani, Grant K.
AU - Frisch, Stephanie
AU - Armbrecht, Eric S.
AU - Lind, Anne C.
AU - Nguyen, Tudung T.
AU - Hassan, Anjum
AU - Kreisel, Friederike H.
AU - Frater, John L.
PY - 2013/3
Y1 - 2013/3
N2 - We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52 years. Diagnosis of myeloid sarcoma in the skin was diff-cult due to the low frequency of myeloperoxidase and/or CD34+ cases (56% and 19% of tested cases, respectively). Seventy-one of the 83 patients (86%) had ≥ 1 bone marrow biopsy. Twenty-eight (39%) had acute myeloid leukemia with monocytic differentiation. Twenty-three had other de novo acute myeloid leukemia subtypes. Thirteen patients had other myeloid neoplasms, of which 4 ultimately progressed to an acute myeloid leukemia. Seven had no bone marrow malignancy. Ninety-eight percent of the patients received chemotherapy, and approximately 89% died of causes related to their disease. Cutaneous myeloid sarcoma in most cases represents an aggressive manifestation of acute myeloid leukemia. Diagnosis can be challenging due to lack of myeloblast-associated antigen expression in many cases, and diffculty in distinguishing monocyte-lineage blasts from neoplastic and non-neoplastic mature monocytes.
AB - We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52 years. Diagnosis of myeloid sarcoma in the skin was diff-cult due to the low frequency of myeloperoxidase and/or CD34+ cases (56% and 19% of tested cases, respectively). Seventy-one of the 83 patients (86%) had ≥ 1 bone marrow biopsy. Twenty-eight (39%) had acute myeloid leukemia with monocytic differentiation. Twenty-three had other de novo acute myeloid leukemia subtypes. Thirteen patients had other myeloid neoplasms, of which 4 ultimately progressed to an acute myeloid leukemia. Seven had no bone marrow malignancy. Ninety-eight percent of the patients received chemotherapy, and approximately 89% died of causes related to their disease. Cutaneous myeloid sarcoma in most cases represents an aggressive manifestation of acute myeloid leukemia. Diagnosis can be challenging due to lack of myeloblast-associated antigen expression in many cases, and diffculty in distinguishing monocyte-lineage blasts from neoplastic and non-neoplastic mature monocytes.
KW - Chloroma
KW - Cutaneous myeloid sarcoma
KW - Mono-blastic sarcoma
KW - Myeloid sarcoma
UR - http://www.scopus.com/inward/record.url?scp=84876969848&partnerID=8YFLogxK
U2 - 10.2340/00015555-1458
DO - 10.2340/00015555-1458
M3 - Article
C2 - 23165700
AN - SCOPUS:84876969848
SN - 0001-5555
VL - 93
SP - 319
EP - 324
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
IS - 3
ER -