@article{63907ff7e3e34dd79685b7f8f54190fa,
title = "Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells",
abstract = "Type 2 immunity is critical for defense against cutaneous infections but also underlies the development of allergic skin diseases. We report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell (ILC2) subset that depended on interleukin 7 (IL-7) and constitutively produced IL-13. Intravital multiphoton microscopy showed that dermal ILC2 cells specifically interacted with mast cells, whose function was suppressed by IL-13. Treatment of mice deficient in recombination-activating gene 1 (Rag1-/-) with IL-2 resulted in the population expansion of activated, IL-5-producing dermal ILC2 cells, which led to spontaneous dermatitis characterized by eosinophil infiltrates and activated mast cells. Our data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.",
author = "Ben Roediger and Ryan Kyle and Yip, \{Kwok Ho\} and Nital Sumaria and Guy, \{Thomas V.\} and Kim, \{Brian S.\} and Mitchell, \{Andrew J.\} and Tay, \{Szun S.\} and Rohit Jain and Elizabeth Forbes-Blom and Xi Chen and Tong, \{Philip L.\} and Bolton, \{Holly A.\} and David Artis and Paul, \{William E.\} and \{De St Groth\}, \{Barbara Fazekas\} and Grimbaldeston, \{Michele A.\} and \{Le Gros\}, Graham and Wolfgang Weninger",
note = "Funding Information: We thank J. Ho Cho and J. Sprent (Garvan Institute) for mice deficient in IL-7, IL-15 or Jak3; M. Kleinschek (DNAX) for Il25−/− mice; P. Besmer (Sloan Kettering Institute) for c-Kit–eGFP mice; Z. Eshar (Weizmann Institute of Science) for mouse SPE-7 hybridoma cells that produce IgE monoclonal antibody specific for 2,4-dinitrophenyl; A. Smith, S. Allen, S. Dervish, C. Zhu, A. Terry, Y. Wen Loh, K. Price and M. Camberis for technical assistance; M. Rizk and J. Qin for animal husbandry; L. Feigenbaum for help in preparing mice with transgenic expression of a bacterial artificial chromosome; N. Kolesnikoff and H. Taing for help with culturing bone marrow–derived mast cells; and L. Cavanagh for administrative assistance. Supported by the Australian National Health and Medical Research Council (M.A.G.), the Health Research Council of New Zealand, the Marjorie Barclay Trust, the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases (US National Institutes of Health) and the Cancer Institute New South Wales (W.W.).",
year = "2013",
month = jun,
doi = "10.1038/ni.2584",
language = "English",
volume = "14",
pages = "564--573",
journal = "Nature immunology",
issn = "1529-2908",
number = "6",
}