Abstract
This article provides an overview of the role of both epitheLial and immune cells in providing host-protective immunity and maintaining homeostasis and their contributions to pathological inflammation in the skin. We outLined important skin-resident adaptive and innate immune cells and their known functions. Specifically, we highLight the role of keratinocytes in directly regulating immunity and inflammation via the production of antimicrobial peptides, chemokines, and cytokines. The role of newly identified subsets of T cells and dendritic cells mediating specific immune pathways is also detailed. Finally, the potential contributions of previously unrecognized innate lymphoid cells, as well as granulocytes and macrophages, to inflammation and repair are described.
| Original language | English |
|---|---|
| Title of host publication | Pathobiology of Human Disease |
| Subtitle of host publication | A Dynamic Encyclopedia of Disease Mechanisms |
| Publisher | Elsevier Inc. |
| Pages | 1145-1147 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780123864567 |
| ISBN (Print) | 9780123864574 |
| DOIs | |
| State | Published - Jan 1 2014 |
Keywords
- Atopic dermatitis
- Basophil
- Dendritic cell
- EpitheLial cell-derived cytokine
- IL-17A
- IL-22
- IL-25
- IL-33
- Innate lymphoid cell
- Keratinocyte
- Langerhans cell
- Psoriasis
- TSLP