Cutaneous desmoplastic melanoma: Reappraisal of morphologic heterogeneity and prognostic factors

Klaus J. Busam, Urvi Mujumdar, Amanda J. Hummer, Jennifer Nobrega, William G. Hawkins, Daniel G. Coit, Mary S. Brady

Research output: Contribution to journalReview articlepeer-review

180 Scopus citations


Desmoplastic melanoma (DM) is a variant of melanoma, which may be confused with nonmelanocytic benign or malignant spindle cell proliferations. The histologic hallmark of DM is the presence of fusiform melanocytes dispersed in a prominent collagenous stroma. Phenotypic heterogeneity of DM is underrecognized. Desmoplasia may be prominent throughout the entire tumor ("pure" DM) or represent a portion of an otherwise nondesmoplastic melanoma ("combined" DM). We reviewed melanomas with desmoplasia from 92 patients seen at a single institution between 1980 and 2002. Fifty-five of the tumors were pure DM. Thirty-seven were classified as combined. Mean follow-up of patients was 46 months for those alive at the last follow-up. Univariate analysis of clinical and pathologic parameters revealed four significant variables for disease-free survival: Clark level (IV vs. V; P = 0.005), DM subtype (pure vs. combined; P = 0.01), tumor mitotic rate (<1, 1-4, >4 mitoses/mm2; P = 0.01), and tumor thickness (<1 mm, 1-4 mm, >4 mm; P = 0.02). Only histologic subtype (P = 0.02) and Clark level (P = 0.05) were independently significant by Cox regression analysis. Our results indicate that distinguishing pure from combined forms of DM is clinically relevant for prognosis (pure forms being associated with longer disease-specific survival). Failure to make this distinction may account for conflicting reports in the literature on the biologic behavior and prognosis of DM.

Original languageEnglish
Pages (from-to)1518-1525
Number of pages8
JournalAmerican Journal of Surgical Pathology
Issue number11
StatePublished - Nov 1 2004


  • Desmoplastic
  • Melanoma
  • Prognostic factors


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