TY - JOUR
T1 - Cutaneous angiosarcoma as a second malignant neoplasm after peripheral primitive neuroectodermal tumor
AU - Coffin, Cheryl M.
AU - Vietti, Teresa J.
AU - Land, Vita J.
AU - Kraybill, William G.
AU - Dehner, Louis P.
PY - 1992
Y1 - 1992
N2 - Second malignant neoplasms (SMN) in late childhood or young adulthood in individuals who have been successfully treated for an initial malignancy have emerged as a late effect of therapy in survivors of childhood cancer. Although radiation therapy is frequently implicated, chemotherapy with alkylating agents and antimetabolites has also been associated with SMN. Soft tissue sarcomas are among the most frequent primary malignancies complicated by a SMN and account for a majority of nonhematolymphoid SMN. We present the clinical and pathologic findings in a patient who had a peripheral neuroepithelioma (primitive neuroectodermal tumor, PNET) of the soft tissues diagnosed at 17 years of age, was treated with high‐dose irradiation and multidrug chemotherapy, and developed an angiosarcoma 14 years later. This case represents an uncommon combination of mesenchymal malignancies in a young patient with an unusually favorable clinical course following the diagnosis of PNET. © 1992 Wiley‐Liss, Inc.
AB - Second malignant neoplasms (SMN) in late childhood or young adulthood in individuals who have been successfully treated for an initial malignancy have emerged as a late effect of therapy in survivors of childhood cancer. Although radiation therapy is frequently implicated, chemotherapy with alkylating agents and antimetabolites has also been associated with SMN. Soft tissue sarcomas are among the most frequent primary malignancies complicated by a SMN and account for a majority of nonhematolymphoid SMN. We present the clinical and pathologic findings in a patient who had a peripheral neuroepithelioma (primitive neuroectodermal tumor, PNET) of the soft tissues diagnosed at 17 years of age, was treated with high‐dose irradiation and multidrug chemotherapy, and developed an angiosarcoma 14 years later. This case represents an uncommon combination of mesenchymal malignancies in a young patient with an unusually favorable clinical course following the diagnosis of PNET. © 1992 Wiley‐Liss, Inc.
KW - angiosarcoma
KW - late effects of therapy
KW - primitive neuroectodermal tumor
KW - radiation‐induced neoplasms
KW - second primary malignant neoplasm
UR - http://www.scopus.com/inward/record.url?scp=0026725179&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950200418
DO - 10.1002/mpo.2950200418
M3 - Article
C2 - 1608360
AN - SCOPUS:0026725179
SN - 0098-1532
VL - 20
SP - 352
EP - 356
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 4
ER -