Current concepts in the design of hydrogels as vitreous substitutes

K. E. Swindle-Reilly, M. A. Reilly, N. Ravi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

13 Scopus citations


In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.

Original languageEnglish
Title of host publicationBiomaterials and Regenerative Medicine in Ophthalmology
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages30
ISBN (Electronic)9780081001844
ISBN (Print)9780081001479
StatePublished - Apr 21 2016


  • Biomimetic
  • Hydrogel
  • Injectable
  • Osmotic pressure
  • Vitreous humor
  • Vitreous substitute


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