Current concepts in the design of hydrogels as vitreous substitutes

K. E. Swindle-Reilly; M. A. Reilly; N. Ravi

doi:10.1016/B978-0-08-100147-9.00005-5

Current concepts in the design of hydrogels as vitreous substitutes

K. E. Swindle-Reilly, M. A. Reilly, N. Ravi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

15 Scopus citations

Abstract

In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.

Original language	English
Title of host publication	Biomaterials and Regenerative Medicine in Ophthalmology
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	101-130
Number of pages	30
ISBN (Electronic)	9780081001844
ISBN (Print)	9780081001479
DOIs	https://doi.org/10.1016/B978-0-08-100147-9.00005-5
State	Published - Apr 21 2016

Keywords

Biomimetic
Hydrogel
Injectable
Osmotic pressure
Vitreous humor
Vitreous substitute

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10.1016/B978-0-08-100147-9.00005-5

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abstract = "In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.",

keywords = "Biomimetic, Hydrogel, Injectable, Osmotic pressure, Vitreous humor, Vitreous substitute",

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AU - Reilly, M. A.

AU - Ravi, N.

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N2 - In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.

AB - In this chapter, the optimization of the design of in situ-forming hydrogel vitreous substitutes is discussed. First, a review of the structure and function, development and growth, and biomechanical properties of the vitreous humor is given. This review provides a foundation for designing a biomimetic vitreous substitute. Past and current treatments for vitreous substitution are also discussed. Recent research advances utilizing hydrogels as vitreous substitutes and proposed solutions for the design of vitreous substitutes are discussed in detail. Particular emphasis is given to the use of in situ-forming hydrogels for vitreous substitution and exploiting the swelling properties of hydrogels to reattach the retina.

KW - Biomimetic

KW - Hydrogel

KW - Injectable

KW - Osmotic pressure

KW - Vitreous humor

KW - Vitreous substitute

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BT - Biomaterials and Regenerative Medicine in Ophthalmology

PB - Elsevier Inc.

ER -

Current concepts in the design of hydrogels as vitreous substitutes

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Keywords

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