TY - JOUR
T1 - Current Concepts in Orthobiologics for Achilles Tendon Injuries
T2 - A Critical Analysis Review
AU - Gopinatth, Varun
AU - Boghosian, Tanya
AU - Perugini, Julia M.
AU - Smith, Matthew V.
AU - Knapik, Derrick M.
N1 - Publisher Copyright:
© 2024 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED.
PY - 2024/11/5
Y1 - 2024/11/5
N2 - Platelet-rich plasma and hyaluronic acid are low-risk and potentially high-reward treatments for Achilles tendinopathy, although clinical studies have yielded mixed results with questionable methodological qualityCase series and reports have reported that bone marrow aspirate, stem cells, and amniotic membrane products can improve functional outcomes, alleviate pain, and facilitate return to sport and activities, but high-level evidence studies are lackingExosomes are a promising novel biologic with laboratory studies showing improved collagen organization and cell proliferation, greater tendon mechanical properties, and prevention of extracellular matrix breakdown.Standardization of protocols with clear reporting is necessary for future studies evaluating orthobiologic therapies for Achilles tendon injuries.
AB - Platelet-rich plasma and hyaluronic acid are low-risk and potentially high-reward treatments for Achilles tendinopathy, although clinical studies have yielded mixed results with questionable methodological qualityCase series and reports have reported that bone marrow aspirate, stem cells, and amniotic membrane products can improve functional outcomes, alleviate pain, and facilitate return to sport and activities, but high-level evidence studies are lackingExosomes are a promising novel biologic with laboratory studies showing improved collagen organization and cell proliferation, greater tendon mechanical properties, and prevention of extracellular matrix breakdown.Standardization of protocols with clear reporting is necessary for future studies evaluating orthobiologic therapies for Achilles tendon injuries.
UR - http://www.scopus.com/inward/record.url?scp=85208603001&partnerID=8YFLogxK
U2 - 10.2106/JBJS.RVW.24.00144
DO - 10.2106/JBJS.RVW.24.00144
M3 - Review article
C2 - 39499787
AN - SCOPUS:85208603001
SN - 2329-9185
VL - 12
JO - JBJS reviews
JF - JBJS reviews
IS - 11
M1 - 00144
ER -