Current Concepts in Orthobiologics for Achilles Tendon Injuries: A Critical Analysis Review

Varun Gopinatth, Tanya Boghosian, Julia M. Perugini, Matthew V. Smith, Derrick M. Knapik

Research output: Contribution to journalReview articlepeer-review

Abstract

Platelet-rich plasma and hyaluronic acid are low-risk and potentially high-reward treatments for Achilles tendinopathy, although clinical studies have yielded mixed results with questionable methodological qualityCase series and reports have reported that bone marrow aspirate, stem cells, and amniotic membrane products can improve functional outcomes, alleviate pain, and facilitate return to sport and activities, but high-level evidence studies are lackingExosomes are a promising novel biologic with laboratory studies showing improved collagen organization and cell proliferation, greater tendon mechanical properties, and prevention of extracellular matrix breakdown.Standardization of protocols with clear reporting is necessary for future studies evaluating orthobiologic therapies for Achilles tendon injuries.

Original languageEnglish
Article number00144
JournalJBJS reviews
Volume12
Issue number11
DOIs
StatePublished - Nov 5 2024

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