Abstract
Extended forms of beta subunits of human glycoproteins wherein the amino acid sequence of a carboxy terminal peptide (CTP) representing positions from about 112-118 to 145 of the human CG-beta subunit or a variant form thereof is appended to the C-terminus are disclosed. Recombinant materials for the production of these extended human glycoprotein beta subunits and production of the modified hormones containing the extended beta subunits are also described. Pharmaceutical compositions containing the modified forms of these hormones are useful in pharmacological applications analogous to those of the unmodified forms.
| Original language | English |
|---|---|
| Pages (from-to) | 768 |
| Number of pages | 1 |
| Journal | Biotechnology Advances |
| Volume | 15 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1997 |