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CTLA-4 can function as a negative regulator of T cell activation
Theresa L. Walunas
,
Deborah J. Lenschow
, Christina Y. Bakker
, Peter S. Linsley
, Gordon J. Freeman
, Jonathan M. Green
, Craig B. Thompson
, Jeffrey A. Bluestone
Division of Rheumatology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Institute of Clinical and Translational Sciences (ICTS)
Siteman Cancer Center
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Rheumatic Diseases Research Resource-Based Center
DBBS - Immunology
DBBS - Molecular Microbiology and Microbial Pathogenesis
Mentorship to Enhance Development in Academia Program
Research output
:
Contribution to journal
›
Article
›
peer-review
1995
Scopus citations
Overview
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Keyphrases
T Cell Activation
100%
Negative Regulator
100%
Cytotoxic T-lymphocyte antigen-4 (CTLA-4)
100%
T Cells
75%
CD28
50%
T Cell Proliferation
50%
CTLA-4 Inhibitors
50%
Antigen Receptor
25%
Homodimer
25%
Costimulatory Molecules
25%
Costimulation
25%
Ligation
25%
Allogeneic
25%
Glycoprotein
25%
Negative Signal
25%
Fab Fragment
25%
Immune Function
25%
Natural Ligands
25%
Antibody Fragment
25%
Anti-CTLA-4
25%
CTLA-4 Receptor
25%
Immunology and Microbiology
T Cell Activation
100%
CTLA-4
100%
T Cell
50%
CD28
33%
T Cell Proliferation
33%
Cytotoxic T Lymphocyte Antigen 4 Antibody
33%
Cross Linking
16%
Glycoprotein
16%
Immunoglobulin F(ab) Fragment
16%