CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers

Mark Hyman Rapaport; Cathy G. McAllister; David Pickar; Lawrence Tamarkin; Darrell G. Kirch; Stephen M. Paul

doi:10.1016/S0920-9964(97)00008-X

CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers

Mark Hyman Rapaport
, Cathy G. McAllister
, David Pickar
, Lawrence Tamarkin
, Darrell G. Kirch
, Stephen M. Paul

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	Schizophrenia research
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/S0920-9964(97)00008-X
State	Published - May 24 1997

Keywords

Biological psychiatry
CSF
IL-1
IL-2
Immunology
Schizophrenia

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10.1016/S0920-9964(97)00008-X

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title = "CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers",

abstract = "It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).",

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AU - Rapaport, Mark Hyman

AU - McAllister, Cathy G.

AU - Pickar, David

AU - Tamarkin, Lawrence

AU - Kirch, Darrell G.

AU - Paul, Stephen M.

PY - 1997/5/24

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N2 - It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).

AB - It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).

KW - Biological psychiatry

KW - CSF

KW - IL-1

KW - IL-2

KW - Immunology

KW - Schizophrenia

UR - https://www.scopus.com/pages/publications/0030911622

U2 - 10.1016/S0920-9964(97)00008-X

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ER -

CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers

Abstract

Keywords

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