It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).
- Biological psychiatry