CSF IL-1 and IL-2 in medicated schizophrenic patients and normal volunteers

Mark Hyman Rapaport, Cathy G. McAllister, David Pickar, Lawrence Tamarkin, Darrell G. Kirch, Stephen M. Paul

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

It is clear that cytokines exert a variety of modulatory actions on the central nervous system. As part of our work exploring the relationship between immune activation and psychosis, we measured cerebrospinal fluid (CSF) IL-1α and IL-2 levels in 60 medicated schizophrenic patients and in 21 normal volunteers using a competitive enzyme immunoassay. The two groups did not differ significantly in their mean cytokine levels: 1.01 (0.149) ng/ml (patients) vs. 1.28 (0.150)ng/ml (controls) for IL-1α and 0.970 (0.038)ng/ml (patients) vs. 1.25 (0.086)ng/ml (controls) for IL-2. There was a significant positive correlation between CSF IL-1α and IL-2 levels for all subjects (r=0.50, n = 44, p = 0.0001).

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalSchizophrenia research
Volume25
Issue number2
DOIs
StatePublished - May 24 1997
Externally publishedYes

Keywords

  • Biological psychiatry
  • CSF
  • IL-1
  • IL-2
  • Immunology
  • Schizophrenia

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