Cryptococcus neoformans, a fungus under stress

Sarah M. Brown, Leona T. Campbell, Jennifer K. Lodge

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses during growth in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutrient deprivation. There have been many genes implicated in resistance to individual stresses. Notably, the catalases do not have the expected role in resistance to external oxidative stress, but specific peroxidases appear to be critical for resistance to both oxidative and nitrosative stresses. Signal transduction through the HOG1 and calcineurin/calmodulin pathways has been implicated in the stress response. Microarray and proteomic analyses have indicated that the common responses to stress are induction of metabolic and oxidative stress genes, and repression of genes encoding translational machinery.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalCurrent Opinion in Microbiology
Volume10
Issue number4
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

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