TY - JOUR
T1 - Cryptococcus neoformans, a fungus under stress
AU - Brown, Sarah M.
AU - Campbell, Leona T.
AU - Lodge, Jennifer K.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2007/8
Y1 - 2007/8
N2 - Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses during growth in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutrient deprivation. There have been many genes implicated in resistance to individual stresses. Notably, the catalases do not have the expected role in resistance to external oxidative stress, but specific peroxidases appear to be critical for resistance to both oxidative and nitrosative stresses. Signal transduction through the HOG1 and calcineurin/calmodulin pathways has been implicated in the stress response. Microarray and proteomic analyses have indicated that the common responses to stress are induction of metabolic and oxidative stress genes, and repression of genes encoding translational machinery.
AB - Cryptococcus neoformans is a human fungal pathogen that survives exposure to stresses during growth in the human host, including oxidative and nitrosative stress, high temperature, hypoxia, and nutrient deprivation. There have been many genes implicated in resistance to individual stresses. Notably, the catalases do not have the expected role in resistance to external oxidative stress, but specific peroxidases appear to be critical for resistance to both oxidative and nitrosative stresses. Signal transduction through the HOG1 and calcineurin/calmodulin pathways has been implicated in the stress response. Microarray and proteomic analyses have indicated that the common responses to stress are induction of metabolic and oxidative stress genes, and repression of genes encoding translational machinery.
UR - http://www.scopus.com/inward/record.url?scp=34548622178&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2007.05.014
DO - 10.1016/j.mib.2007.05.014
M3 - Review article
C2 - 17707685
AN - SCOPUS:34548622178
VL - 10
SP - 320
EP - 325
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 4
ER -