Crosstalk between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

Andrew S. Yoo; Carlos Bais; Iva Greenwald

doi:10.1126/science.1091639

Crosstalk between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

Andrew S. Yoo, Carlos Bais, Iva Greenwald

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1° fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2° fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2° cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.

Original language	English
Pages (from-to)	663-666
Number of pages	4
Journal	Science
Volume	303
Issue number	5658
DOIs	https://doi.org/10.1126/science.1091639
State	Published - Jan 30 2004

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abstract = "The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor-mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1° fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2° fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2° cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.",

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UR - https://www.scopus.com/pages/publications/0442272485

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Crosstalk between the EGFR and LIN-12/Notch Pathways in C. elegans Vulval Development

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