TY - JOUR
T1 - Cross-Sectional and Prospective Associations between Parkinsonism and Parkinson's Disease with Frailty in Latin America
AU - Kim, Dani J.
AU - Khan, Nusrat
AU - Llibre-Rodriguez, Juan J.
AU - Jiang, Miao
AU - Rodriguez-Salgado, Ana M.
AU - Acosta, Isaac
AU - Sosa, Ana Luisa
AU - Acosta, Daisy
AU - Jimenez-Velasquez, Ivonne Z.
AU - Guerra, Mariella
AU - Salas, Aquiles
AU - Sánchez, Nedelys Díaz
AU - López-Contreras, Ricardo
AU - Hesse, Heike
AU - Tanner, Caroline
AU - Llibre-Guerra, Jorge J.
AU - Prina, Matthew
N1 - Publisher Copyright:
© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
PY - 2024/12
Y1 - 2024/12
N2 - Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America. Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population. Methods: 12,865 older adults (aged ≥65 years) from the 10/66 population-based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross-sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed-effect meta-analysis. In non-frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality. Results: At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause-specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism. Conclusion: Parkinsonism and PD were cross-sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.
AB - Background: Little is known about the relationship between parkinsonism or Parkinson's disease (PD) and frailty in Latin America. Objective: The study aimed to determine the cross-sectional and prospective associations between parkinsonism and PD with frailty in a large multi-country cohort in Latin America. Frailty was assessed using three different models to explore which definitions are more appropriate to screen for frailty in a PD population. Methods: 12,865 older adults (aged ≥65 years) from the 10/66 population-based cohort study in six Latin American countries were analyzed. Logistic regression models assessed the cross-sectional association between parkinsonism/PD with baseline frailty. Individual country analyses were combined via fixed-effect meta-analysis. In non-frail participants who were followed up for 4 years, Cox proportional hazards regression models assessed the prospective association between parkinsonism/PD with incident frailty accounting for competing risk of mortality. Results: At baseline, the prevalence of parkinsonism and PD was 7% and 2%, respectively, and the prevalence of frailty varied across the three models with rates of 18% for frailty phenotype, 20% for frailty index and 30% for multidimensional frailty model. PD was associated with baseline and incident frailty after accounting for age, sex, and education: odds ratios and 95% confidence intervals (95% CI) for frailty were 2.49 (95% CIs 1.87–3.31), 2.42 (95% CIs 1.80–3.25), and 1.57 (95% CIs 1.16–2.21), and cause-specific hazard ratios were 1.66 (95% CIs 1.07–2.56), 1.78 (95% CIs 1.05–3.03), and 1.58 (95% CIs 0.91–2.74). Similar results were found for parkinsonism. Conclusion: Parkinsonism and PD were cross-sectionally and prospectively associated with frailty in Latin America. Routine screening for frailty in PD patients may aid earlier detection of those at greater risk of adverse outcomes.
KW - Latin America
KW - Parkinson's disease
KW - epidemiology
KW - frailty
UR - http://www.scopus.com/inward/record.url?scp=85204348812&partnerID=8YFLogxK
U2 - 10.1002/mdc3.14214
DO - 10.1002/mdc3.14214
M3 - Article
C2 - 39305017
AN - SCOPUS:85204348812
SN - 2330-1619
VL - 11
SP - 1489
EP - 1499
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
IS - 12
ER -