TY - JOUR
T1 - Crohn's Disease Is Associated With an Increased Prevalence of Nonalcoholic Fatty Liver Disease
T2 - A Cross-Sectional Study Using Magnetic Resonance Proton Density Fat Fraction Mapping
AU - McHenry, Scott
AU - Sharma, Yeshika
AU - Tirath, Ankita
AU - Tsai, Richard
AU - Mintz, Aaron
AU - Fraum, Tyler J.
AU - Salter, Amber
AU - Browning, Jeffrey D.
AU - Flores, Avegail G.
AU - Davidson, Nicholas O.
AU - Fowler, Kathryn J.
AU - Ciorba, Matthew A.
AU - Deepak, Parakkal
N1 - Funding Information:
Funding Scott McHenry is supported by an Institutional National Research Service Award (T32-DK007130-45). Nicholas O. Davidson supported by grants DK-56260, HL-38180 and DK-112378. PD is supported by a Junior Faculty Development Award from the American College of Gastroenterology. Matthew A. Ciorba is supported by DK109384, a Crohn's and Colitis Foundation Daniel H. Present Senior Research Award (Ref. 370763) and philanthropic support from the Givin’ it all for Guts Foundation (https://givinitallforguts.org) and the Lawrence C. Pakula MD IBD Research Innovation and Education Fund. The work performed in this paper was additionally supported by grants provided by the National Institute of Health through the Washington University in Saint Louis’ Digestive Disease Research Core (P30 DK052574). Additional grant support for the REDCap database was provided by the Clinical and Translational Science Award (UL1 TR000448) and Siteman Cancer Center Support Grant (P30-CA091842). This work supported in part by grant UL1TR001105 from the National Center for Advancing Translational Science, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Center for Translational Medicine, The University of Texas Southwestern Medical Center and its affiliated academic and health care centers, the National Center for Advancing Translational Sciences, or the National Institutes of Health.
Funding Information:
Funding Scott McHenry is supported by an Institutional National Research Service Award (T32-DK007130-45). Nicholas O. Davidson supported by grants DK-56260, HL-38180 and DK-112378. PD is supported by a Junior Faculty Development Award from the American College of Gastroenterology. Matthew A. Ciorba is supported by DK109384, a Crohn's and Colitis Foundation Daniel H. Present Senior Research Award (Ref. 370763)and philanthropic support from the Givin’ it all for Guts Foundation (https://givinitallforguts.org)and the Lawrence C. Pakula MD IBD Research Innovation and Education Fund. The work performed in this paper was additionally supported by grants provided by the National Institute of Health through the Washington University in Saint Louis’ Digestive Disease Research Core (P30 DK052574). Additional grant support for the REDCap database was provided by the Clinical and Translational Science Award (UL1 TR000448)and Siteman Cancer Center Support Grant (P30-CA091842). This work supported in part by grant UL1TR001105 from the National Center for Advancing Translational Science, National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Center for Translational Medicine, The University of Texas Southwestern Medical Center and its affiliated academic and health care centers, the National Center for Advancing Translational Sciences, or the National Institutes of Health.
Publisher Copyright:
© 2019 AGA Institute
PY - 2019/12
Y1 - 2019/12
N2 - Nonalcoholic fatty liver disease (NAFLD) commonly coexists with Crohn's disease (CD); however, it remains unclear if it is more prevalent than would be expected as ultrasound surveys of CD patients report a very wide range of prevalence (9%–40%).1–3 To address this uncertainty, we performed a prospective, cross-sectional survey of NAFLD in CD patients by generating magnetic resonance proton density fat fraction (MR-PDFF) maps as compared with 2 control populations. MR-PDFF provides a quantitative, sensitive and specific (97% and 100%, respectively) radiographic surrogate for liver fat.4
AB - Nonalcoholic fatty liver disease (NAFLD) commonly coexists with Crohn's disease (CD); however, it remains unclear if it is more prevalent than would be expected as ultrasound surveys of CD patients report a very wide range of prevalence (9%–40%).1–3 To address this uncertainty, we performed a prospective, cross-sectional survey of NAFLD in CD patients by generating magnetic resonance proton density fat fraction (MR-PDFF) maps as compared with 2 control populations. MR-PDFF provides a quantitative, sensitive and specific (97% and 100%, respectively) radiographic surrogate for liver fat.4
UR - http://www.scopus.com/inward/record.url?scp=85065246220&partnerID=8YFLogxK
U2 - 10.1016/j.cgh.2019.02.045
DO - 10.1016/j.cgh.2019.02.045
M3 - Short survey
C2 - 30876963
AN - SCOPUS:85065246220
SN - 1542-3565
VL - 17
SP - 2816
EP - 2818
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 13
ER -