Crohn disease: A current perspective on genetics, autophagy and immunity

Thaddeus S. Stappenbeck, John D. Rioux, Atsushi Mizoguchi, Tatsuya Saitoh, Alan Huett, Arlette Darfeuille-Michaud, Tom Wileman, Noboru Mizushima, Simon Carding, Shizuo Akira, Miles Parkes, Ramnik J. Xavier

Research output: Contribution to journalReview article

75 Scopus citations

Abstract

Crohn disease (CD) is a chronic and debilitating inflammatory condition of the gastrointestinal tract.1 Prevalence in western populations is 100-150/100,000 and somewhat higher in Ashkenazi Jews. Peak incidence is in early adult life, although any age can be affected and a majority of affected individuals progress to relapsing and chronic disease. Medical treatments rely significantly on empirical corticosteroid therapy and immunosuppression, and intestinal resectional surgery is frequently required. Thus, 80% of patients with CD come to surgery for refractory disease or complications. It is hoped that an improved understanding of pathogenic mechanisms, for example by studying the genetic basis of CD and other forms of inflammatory bowel diseases (IBD), will lead to improved therapies and possibly preventative strategies in individuals identified as being at risk.

Original languageEnglish
Pages (from-to)355-374
Number of pages20
JournalAutophagy
Volume7
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • Atg16L1
  • Dendritic cells
  • Gastrointestinal
  • Genome-wide association
  • Gut microbiota
  • IRGM
  • Inflammatory bowel diseases
  • Paneth cell
  • Ulcerative colitis

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  • Cite this

    Stappenbeck, T. S., Rioux, J. D., Mizoguchi, A., Saitoh, T., Huett, A., Darfeuille-Michaud, A., Wileman, T., Mizushima, N., Carding, S., Akira, S., Parkes, M., & Xavier, R. J. (2011). Crohn disease: A current perspective on genetics, autophagy and immunity. Autophagy, 7(4), 355-374. https://doi.org/10.4161/auto.7.4.13074