Critical role of autophagy in ischemia/reperfusion injury to aged livers

Jin Hee Wang, Kevin E. Behrns, Christiaan Leeuwenburgh, Jae Sung Kim

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations

Abstract

A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sensitivity of the liver to I/R injury with age. Our work suggests that a restoration or enhancement of autophagy is a novel therapeutic modality to ameliorate liver function after I/R to aged livers.

Original languageEnglish
Pages (from-to)140-141
Number of pages2
JournalAutophagy
Volume8
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Aging
  • Autophagy
  • Ischemia
  • Liver
  • Mitochondria
  • Reperfusion

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