TY - JOUR
T1 - Critical review of the management of primary central nervous nongerminomatous germ cell tumors
AU - Abu Arja, Mohammad H.
AU - Bouffet, Eric
AU - Finlay, Jonathan L.
AU - AbdelBaki, Mohamed S.
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/6
Y1 - 2019/6
N2 - Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor. There is an obvious need to incorporate molecular studies within prospective clinical trials that will likely lead to the incorporation of targeted, more effective future treatment strategies.
AB - Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor. There is an obvious need to incorporate molecular studies within prospective clinical trials that will likely lead to the incorporation of targeted, more effective future treatment strategies.
KW - central nervous system
KW - germ cell tumors
KW - mixed malignant germ cell tumors
KW - nongerminomatous germ cell tumors
KW - pediatrics brain tumors
UR - http://www.scopus.com/inward/record.url?scp=85061569342&partnerID=8YFLogxK
U2 - 10.1002/pbc.27658
DO - 10.1002/pbc.27658
M3 - Review article
C2 - 30767415
AN - SCOPUS:85061569342
SN - 1545-5009
VL - 66
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
IS - 6
M1 - e27658
ER -