Critical review of the management of primary central nervous nongerminomatous germ cell tumors

Mohammad H. Abu Arja, Eric Bouffet, Jonathan L. Finlay, Mohamed S. AbdelBaki

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Multimodal strategies have significantly improved the outcomes for patients with central nervous system nongerminomatous germ cell tumors. Two large cooperative group studies have recently reported much improved outcomes compared with historical series. However, a substantial proportion of patients still attain inadequate responses to initial chemotherapy prior to irradiation, with adverse impact upon survival; optimal induction chemotherapy regimens and radiotherapy strategies are as yet unidentified. Outcomes for patients with relapsed disease remain poor. There is an obvious need to incorporate molecular studies within prospective clinical trials that will likely lead to the incorporation of targeted, more effective future treatment strategies.

Original languageEnglish
Article numbere27658
JournalPediatric Blood and Cancer
Volume66
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • central nervous system
  • germ cell tumors
  • mixed malignant germ cell tumors
  • nongerminomatous germ cell tumors
  • pediatrics brain tumors

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