Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention

Sharmistha Dey; Abhay Kumar Singh; Abhinay Kumar Singh; Kartik Rawat; Joyita Banerjee; Vertica Agnihotri; Deepak Upadhaya

doi:10.1007/s12032-021-01633-4

Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention

Sharmistha Dey, Abhay Kumar Singh, Abhinay Kumar Singh, Kartik Rawat, Joyita Banerjee, Vertica Agnihotri, Deepak Upadhaya

Department of Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.

Original language	English
Article number	30
Journal	Medical Oncology
Volume	39
Issue number	3
DOIs	https://doi.org/10.1007/s12032-021-01633-4
State	Published - Mar 2022

Keywords

Biomarker
Oral cancer
PI3K/AKT/mTOR
Ras/Raf/MEK/ERK
Therapeutic

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10.1007/s12032-021-01633-4

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title = "Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention",

abstract = "The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.",

keywords = "Biomarker, Oral cancer, PI3K/AKT/mTOR, Ras/Raf/MEK/ERK, Therapeutic",

author = "Sharmistha Dey and Singh, {Abhay Kumar} and Singh, {Abhinay Kumar} and Kartik Rawat and Joyita Banerjee and Vertica Agnihotri and Deepak Upadhaya",

note = "Funding Information: Not funded by any funding agency. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s12032-021-01633-4",

language = "English",

volume = "39",

journal = "Medical Oncology",

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T1 - Critical pathways of oral squamous cell carcinoma

T2 - molecular biomarker and therapeutic intervention

AU - Dey, Sharmistha

AU - Singh, Abhay Kumar

AU - Singh, Abhinay Kumar

AU - Rawat, Kartik

AU - Banerjee, Joyita

AU - Agnihotri, Vertica

AU - Upadhaya, Deepak

PY - 2022/3

Y1 - 2022/3

N2 - The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.

AB - The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.

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KW - Oral cancer

KW - PI3K/AKT/mTOR

KW - Ras/Raf/MEK/ERK

KW - Therapeutic

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DO - 10.1007/s12032-021-01633-4

M3 - Review article

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VL - 39

JO - Medical Oncology

JF - Medical Oncology

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Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention

Abstract

Keywords

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