Critical Illness Myopathy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Original languageEnglish
Title of host publicationInternational Neurology
Subtitle of host publicationA Clinical Approach
PublisherWiley Blackwell
Pages447-448
Number of pages2
ISBN (Print)9781405157384
DOIs
StatePublished - May 18 2010

Keywords

  • CIM incidence in patients - depending on definition of syndrome
  • CIM, developing in patients - in intensive care unit with acute medical illnesses, as asthma, chronic obstructive pulmonary disease, sepsis
  • CIM, differentiated from central nervous system and neuromuscular disorders
  • Critical illness myopathy (CIM), weakness with inexcitable membranes and loss of myosin and thick filaments in muscle fibers
  • Major pathophysiological changes in CIM - selective loss of major contractile protein (myosin) and inexcitability of muscle membrane
  • Muscle biopsy, confirming diagnosis - in ruling out potentially treatable causes of weakness
  • Serum creatine kinase (CK) level, high in patients during first 2 weeks

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