TY - JOUR
T1 - Critical care management of right ventricular failure in pediatric left ventricular assist devices
T2 - An advanced cardiac therapies improving outcomes network (ACTION) endorsed statement
AU - Rabinowitz, Edon J.
AU - Ghanayem, Nancy
AU - Wright, Lydia
AU - Bigelow, Amee M.
AU - Govardhan, Shilpa V.
AU - Neumayr, Tara M.
AU - Perry, Tanya
AU - Patel, Meghna D.
AU - Niebler, Robert A.
AU - Engelhardt, Kevin P.
AU - Diaz, Isaura
AU - Philip, Joseph
AU - Butto, Arene
AU - Adachi, Iki
AU - Peng, David M.
AU - Kwiatkowski, David
AU - Tume, Sebastian C.
N1 - Publisher Copyright:
© 2025 International Society for Heart and Lung Transplantation
PY - 2025/11
Y1 - 2025/11
N2 - The care of the right ventricle (RV) following left ventricular assist device (LVAD) implantation remains a major clinical challenge, with right ventricular failure (RVF) contributing significantly to morbidity and mortality. While much of the literature focuses on preoperative risk stratification and long-term management, there is limited guidance on the immediate postoperative period from a critical care perspective, particularly in pediatric patients. This review aims to provide practical guidance on the bedside management of the RV in the perioperative period following LVAD implantation in children with biventricular circulation, offering a framework for optimizing RV function and preventing failure. We discuss the pathophysiology of RVF in this setting, highlight key hemodynamic principles, and explore targeted interventions including volume management, inotropic and pulmonary vasodilator support, ventilatory strategies, mechanical circulatory support options, and strategies to mitigate secondary organ dysfunction. By addressing these pediatric-specific critical care considerations, we aim to assist bedside providers in optimizing outcomes for children undergoing LVAD implantation.
AB - The care of the right ventricle (RV) following left ventricular assist device (LVAD) implantation remains a major clinical challenge, with right ventricular failure (RVF) contributing significantly to morbidity and mortality. While much of the literature focuses on preoperative risk stratification and long-term management, there is limited guidance on the immediate postoperative period from a critical care perspective, particularly in pediatric patients. This review aims to provide practical guidance on the bedside management of the RV in the perioperative period following LVAD implantation in children with biventricular circulation, offering a framework for optimizing RV function and preventing failure. We discuss the pathophysiology of RVF in this setting, highlight key hemodynamic principles, and explore targeted interventions including volume management, inotropic and pulmonary vasodilator support, ventilatory strategies, mechanical circulatory support options, and strategies to mitigate secondary organ dysfunction. By addressing these pediatric-specific critical care considerations, we aim to assist bedside providers in optimizing outcomes for children undergoing LVAD implantation.
KW - Guide
KW - Left ventricular assist device
KW - Mechanical circulatory support
KW - Mechanical ventilation
KW - Pediatric cardiac critical care
KW - Right ventricular failure
KW - Subpulmonary failure
UR - https://www.scopus.com/pages/publications/105014760385
U2 - 10.1016/j.jhlto.2025.100361
DO - 10.1016/j.jhlto.2025.100361
M3 - Article
C2 - 40979520
AN - SCOPUS:105014760385
SN - 2950-1334
VL - 10
JO - JHLT Open
JF - JHLT Open
M1 - 100361
ER -