CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants

Keyphrases

• Titin 100%
• Haploinsufficiency 100%
• Functional Deficits 100%
• Truncation Variants 100%
• CRISPR Activation 100%
• Protein Level 17%
• Sarcomere 17%
• Three-dimensional (3D) 11%
• Pathogenicity 11%
• Cardiomyocytes 11%
• Dilated Cardiomyopathy 11%
• Induced Pluripotent Stem Cells (iPSCs) 5%
• RNA Sequencing (RNA-seq) 5%
• High Morbidity 5%
• High Mortality 5%
• MiRNA Target 5%
• Mortality Rate 5%
• Contractile Function 5%
• Regulatory Elements 5%
• Therapeutic Targeting 5%
• Genetic Mechanism 5%
• Molecular Consequences 5%
• Genetic Lesions 5%
• Protein Isoforms 5%
• Single Guide RNA (sgRNA) 5%
• Reporter Assay 5%
• Protein S Deficiency 5%
• Morbidity Rate 5%
• Truncated Protein 5%
• Stem Cell Models 5%
• Incomplete Knowledge 5%
• Agarose Gel Electrophoresis 5%
• Human Cardiomyocytes 5%
• Promoter Elements 5%
• Spatial Proximity 5%
• Guide RNA (gRNA) 5%
• Chromatin Interactions 5%
• DNA Regulatory Elements 5%
• Myofibril Assembly 5%
• Cardiac Microtissues 5%
• Epigenetic Assay 5%
• Isoform Sequencing 5%
• DCas9-VPR 5%

Biochemistry, Genetics and Molecular Biology

• Titin 100%
• Haploinsufficiency 100%
• CRISPR Activation 100%
• Cardiac Muscle Cell 17%
• Promoter Region 11%
• Regulatory Element 11%
• Guide RNA 11%
• Epigenetics 5%
• Induced Pluripotent Stem Cell 5%
• RNA Sequence 5%
• Genetics 5%
• Isoform 5%
• Genetic Mechanism 5%
• Mortality Rate 5%
• Myofibril 5%
• Agarose Gel Electrophoresis 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Connectin 100%
• Congestive Cardiomyopathy 11%
• Pathogenicity 11%
• Guide RNA 11%
• Mortality Rate 5%
• RNA-Sequencing 5%
• Agarose Gel Electrophoresis 5%
• Diseases 5%