Creutzfeldt-Jakob disease with extensive degeneration of white matter

Tae Sung Park, George M. Kleinman, Edward P. Richardson

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Degeneration of the white matter is uncommon in Creutzfeldt-Jakob disease (CJD), and when it occurs is usually mild, and limited in distribution. In the case of a 77-year-old woman with CJD lasting 1 year, there was extensive degeneration of cerebral white matter in addition to severe loss of neurons and hypertrophic astrogliosis in cortex and striatum. The extent and severity of white matter lesions makes the case unusual.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalActa Neuropathologica
Issue number3
StatePublished - Jan 1980


  • Creutzfeldt-Jakob disease
  • Spongiform encephalopathy
  • White-matter degeneration


Dive into the research topics of 'Creutzfeldt-Jakob disease with extensive degeneration of white matter'. Together they form a unique fingerprint.

Cite this