CREST maps somatic structural variation in cancer genomes with base-pair resolution

Jianmin Wang, Charles G. Mullighan, John Easton, Stefan Roberts, Sue L. Heatley, Jing Ma, Michael C. Rusch, Ken Chen, Christopher C. Harris, Li Ding, Linda Holmfeldt, Debbie Payne-Turner, Xian Fan, Lei Wei, David Zhao, John C. Obenauer, Clayton Naeve, Elaine R. Mardis, Richard K. Wilson, James R. DowningJinghui Zhang

Research output: Contribution to journalArticlepeer-review

387 Scopus citations


We developed 'clipping reveals structure' (CREST), an algorithm that uses next-generation sequencing reads with partial alignments to a reference genome to directly map structural variations at the nucleotide level of resolution. Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias (T-ALLs) and a human melanoma cell line, COLO-829, identified 160 somatic structural variations. Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy.

Original languageEnglish
Pages (from-to)652-654
Number of pages3
JournalNature Methods
Issue number8
StatePublished - Aug 2011


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