@article{9e24cf18b609471fbb55f03d8473ae06,
title = "CREST maps somatic structural variation in cancer genomes with base-pair resolution",
abstract = "We developed 'clipping reveals structure' (CREST), an algorithm that uses next-generation sequencing reads with partial alignments to a reference genome to directly map structural variations at the nucleotide level of resolution. Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias (T-ALLs) and a human melanoma cell line, COLO-829, identified 160 somatic structural variations. Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy.",
author = "Jianmin Wang and Mullighan, {Charles G.} and John Easton and Stefan Roberts and Heatley, {Sue L.} and Jing Ma and Rusch, {Michael C.} and Ken Chen and Harris, {Christopher C.} and Li Ding and Linda Holmfeldt and Debbie Payne-Turner and Xian Fan and Lei Wei and David Zhao and Obenauer, {John C.} and Clayton Naeve and Mardis, {Elaine R.} and Wilson, {Richard K.} and Downing, {James R.} and Jinghui Zhang",
note = "Funding Information: This study was supported by St. Jude Children{\textquoteright}s Research Hospital–Washington University Pediatric Cancer Genome Project, Cancer Center support grant P30 CA021765 from the US National Cancer Institute and the American Lebanese Syrian Associated Charities of St. Jude Children{\textquoteright}s Research Hospital. We thank K. Ye for stimulating discussion on the analysis of the COLO-829 cell line. C.G.M. is supported as a Pew Scholar in the Biomedical Sciences. S.L.H. was supported by a Haematology Society of Australasia Travelling Fellowship.",
year = "2011",
month = aug,
doi = "10.1038/nmeth.1628",
language = "English",
volume = "8",
pages = "652--654",
journal = "Nature Methods",
issn = "1548-7091",
number = "8",
}