COVID-19 Vaccine Reactogenicity and Vaccine Attitudes among Children and Parents/Guardians after Multisystem Inflammatory Syndrome in Children or COVID-19 Hospitalization: September 2021 - May 2022

Anna R. Yousaf, Amber Kunkel, Joseph Y. Abrams, Ami B. Shah, Teresa A. Hammett, Kathryn E. Arnold, Yajira L. Beltran, Federico R. Laham, Carol M. Kao, David A. Hunstad, Laila Hussaini, Nadine Baida, Luis Salazar, Maria A. Perez, Christina A. Rostad, Shana Godfred-Cato, Angela P. Campbell, Ermias D. Belay

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: Multisystem inflammatory syndrome in children (MIS-C) is a multiorgan hyperinflammatory condition following SARS-CoV-2 infection. Data on COVID-19 vaccine adverse events and vaccine attitudes in children with prior MIS-C are limited. We described characteristics associated with COVID-19 vaccination, vaccine adverse events and vaccine attitudes in children with a history of MIS-C or COVID-19 and their parents/guardians. Methods: We enrolled children previously hospitalized for MIS-C or COVID-19 from 3 academic institutions. We abstracted charts and interviewed children and parents/guardians regarding vaccine adverse events and acceptability. Results: Of 163 vaccine-eligible children enrolled with a history of MIS-C and 70 with history of COVID-19, 51 (31%) and 34 (49%), respectively, received mRNA COVID-19 vaccine a median of 10 (Interquartile Range 6-13) months after hospital discharge. Among 20 children with MIS-C and parents/guardians who provided interviews, local injection site reaction of brief duration (mean 1.8 days) was most commonly reported; no children required medical care within 2 weeks postvaccination. Vaccine survey results of interviewed, vaccinated children and their parents/guardians: of 20 children with MIS-C and 15 children with COVID-19, 17 (85%) and 13 (87%), respectively, listed doctors in the top 3 most trusted sources for vaccine information; 13 (65%) and 9 (60%) discussed vaccination with their doctor. Conclusions: COVID-19 vaccination was well tolerated in children with prior MIS-C or COVID-19 participating in our investigation. Parents/guardians regarded their children's doctors as a trusted source of information for COVID-19 vaccines, and most vaccinated children's parents/guardians had discussed COVID-19 vaccination for their child with their doctor.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalPediatric Infectious Disease Journal
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2023

Keywords

  • COVID-19
  • MIS-C
  • adverse events
  • vaccine

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