COVID-19 disease and immune dysregulation

Ethan Davitt; Colin Davitt; Monty B. Mazer; Sathya S. Areti; Richard S. Hotchkiss; Kenneth E. Remy

doi:10.1016/j.beha.2022.101401

COVID-19 disease and immune dysregulation

Ethan Davitt, Colin Davitt, Monty B. Mazer, Sathya S. Areti, Richard S. Hotchkiss, Kenneth E. Remy

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was originally dominated by innate cytokine changes, which has since been replaced with a more complex picture of innate and adaptive changes characterized by simultaneous hyperinflammatory and immunosuppressive phenomena in effector cells. These intricacies are summarized in this review as well as potential relevance from acute infection to a multisystem inflammatory syndrome commonly seen in children. Additional consideration is made for the influence of variant to variant host cellular changes and the impact of potential vaccination upon these phenotypes. Finally, therapeutic benefit for immune alterations are discussed.

Original language	English
Article number	101401
Journal	Best Practice and Research: Clinical Haematology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.beha.2022.101401
State	Published - Sep 2022

Keywords

Adaptive
COVID-19
Host immune response
Immunology
Innate
SARS-CoV-2

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10.1016/j.beha.2022.101401

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abstract = "The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was originally dominated by innate cytokine changes, which has since been replaced with a more complex picture of innate and adaptive changes characterized by simultaneous hyperinflammatory and immunosuppressive phenomena in effector cells. These intricacies are summarized in this review as well as potential relevance from acute infection to a multisystem inflammatory syndrome commonly seen in children. Additional consideration is made for the influence of variant to variant host cellular changes and the impact of potential vaccination upon these phenotypes. Finally, therapeutic benefit for immune alterations are discussed.",

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COVID-19 disease and immune dysregulation

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